|Children||Meg Griffin Stewie Griffin|
|Voiced by||Alex Borstein|
|First Episode||Death Has a Shadow|
Lois Griffin (Pewterschmidt being her maiden name) came from a rich family. She married Peter Griffin when he was working as a towel boy in her Father's mansion. She has three children, Meg, Chris, and Stewie. She is piano teacher and works from home. She is "hated" by her one-year old son, Stewie, who often attempts to kill her.
Lois has often proven to be the voice of reason.