Lois finds a picture of her family that includes a brother she never knew she had. She realizes that her brother is in a mental institution. Her brother, Patrick tells Lois that he was put in the asylum after seeing his mother having an affair with Jackie Gleason. It scarred him very badly. Lois decides to take Patrick home. Little does she know that Patrick hates every fat person who reminds him of Jackie Gleason.
In the meantime, Peter Griffin, who is a lot like Jackie Gleason starts his crusade against people that hate fat people. He starts a club just for fat people. People in his club start dying every minute. After Lois finally realizes that The Fat Guy Strangler has to be Patrick, she has to stop her brother before he gets to Peter.